Иммунопатогенез острого панкреатита
https://doi.org/10.23934/2223-9022-2022-11-3-484-492
Аннотация
Лидирующие позиции по частоте, тяжести течения и высокой смертности занимают инфицированные формы острого панкреатита. Однако изучены не все патофизиологические механизмы развития этой патологии. С учетом того, что иммунные реакции являются неотъемлемой частью патогенеза панкреатита, крайне важно изучить взаимосвязь механизмов воспаления и активации иммунного ответа. В этом обзоре будет обсуждена роль различных популяций клеток врожденного иммунитета, включая макрофаги, нейтрофилы, дендритные и тучные клетки, и регуляторных иммунных клеток в патогенезе деструкции тканей железы и взаимосвязи иммунных реакций и синдрома системного воспалительного ответа. Нацеливание на популяции врожденных иммунных клеток и сигнальные пути метаболитов при остром панкреатите может привести к более широкому и, в конечном счете, более эффективному изменению направления программы лечения в сторону разрешения заболевания и улучшения клинических результатов.
Об авторе
Г. В. Булава
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия
Россия
Булава Галина Владимировна доктор медицинских наук, научный консультант, лаборатория клинической иммунологии
129090, Москва, Б. Сухаревская пл., д. 3
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Булава Г.В. Иммунопатогенез острого панкреатита. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2022;11(3):484-492. https://doi.org/10.23934/2223-9022-2022-11-3-484-492
For citation:
Bulava G.V. Immunopathogenesis of Acute Pancreatitis. Russian Sklifosovsky Journal "Emergency Medical Care". 2022;11(3):484-492. https://doi.org/10.23934/2223-9022-2022-11-3-484-492
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